MCT student, Lisa Dwane, talks about her research and recent achievements

cropped-RCSI-logo-1.jpgFollowing completion of my Pharmacology degree in UCD, I began a PhD in breast cancer research under the supervision of Dr. Darran O’Connor, a career I have always been very determined to follow. My research is focused on endocrine-driven breast cancer and understanding the molecular mechanisms that drive this subtype of cancer. Currently, half of breast cancer patients that receive anti-endocrine therapies will relapse, so there is an urgent need for the identification of novel therapeutic targets. Our research is focused on the deubiquitinating enzyme USP11, which we believe plays a key role in driving endocrine-driven breast cancer. When we silence USP11 in vitro, we see a reduction in estrogen receptor activity and cell viability. During the final year of my PhD, I hope to elucidate the mechanism by which USP11 plays this role, and determine the prognostic relevance of USP11 in breast cancer. This could potentially lead to a better understanding of endocrine-driven breast cancer and with further validation, USP11 may represent a novel therapeutic target.

Lisa Dwane presents her research at the Irish Cancer Society’s Researcher of the Year Award. december, 1st, 2016. TCD
Lisa Dwane presents her research at the Irish Cancer Society’s Researcher of the Year Award. December, 1st, 2016. TCD

As a pharmacologist, I was thrilled to win best oral presentation at the Irish Association of Pharmacologists Annual Meeting! The standard of talks throughout the day were excellent, with a wide range of topics explored. I was also a finalist for the Irish Cancer Society’s Researcher of the Year Award, which took place 1st December at Trinity College Dublin. The purpose of the evening was to communicate our research to a lay audience, which proved more difficult than expected! Although I didn’t take home the award it was a very enjoyable evening, and the experience was invaluable. As scientists it is important for us to share and communicate our research with the general public and this was a skill I gained from the night!

Winners and finalists for the Irish Cancer Society’s Researcher of the Year Award
Winners and finalists for the Irish Cancer Society’s Researcher of the Year Award

Dr HH Stewart Award to Aya Al-Hasani

MCT is delighted to report that Aya Al-Hasani, one of our undergraduate Medical Students, has come second place in the Biochemistry Section of National Universities of Ireland, Dr HH Stewart Award. The top three students from RCSI are invited to take part in the exams, for each category.  Students are sent the essay title a week in advance, are not allowed to confer with staff, and sit the essay under exam conditions.

 Aya reflects on her award:

Aya AL-Hasani at Royal Hospital Kilmainham, Wednesday 09 November 2016. http://www.nui.ie/images/news/2016/awards2016_Flash/index.asp
Aya AL-Hasani at Royal Hospital Kilmainham, Wednesday 09 November 2016.
http://www.nui.ie/images/news/2016/awards2016_Flash/index.asp

During my first few years at RCSI, my hardest subject was biochemistry. Those complicated signalling pathways seemed absolutely useless to learn at that time. I then started to realise that biochemistry is essentially the platform for understanding all diseases and treatments. Suddenly, biochemistry became my favourite subject! I was so inspired by Prof. Cavalleri, MCT, who was organised and passionate in his teaching. I chose my favourite topic “obesity” after being invited to sit the HH Stewart exam. I was delighted to know that I won the second prize. It meant a lot for me to compete and win an Irish national competition. I just wished my parents were able to see me in the ceremony.

Aya attended the ceremony at Royal Hospital Kilmainham on Wednesday 09 November 2016.

Well done Aya!