Medical Education

MCT Research Forum – April, 8th 2019 at 12.00

Prof. Judy Harmey: ‘USMLEs. What’s it all about?’

Dr. Sarah O’Neill: ‘Leaning in on TBL’

Dr. Orna Tighe: ‘Qualitative research; A beginners experience’

Chair: Prof. Dermot Cox

Start Time 12.00- 1.00

Cheyne Lecture Theatre

A light lunch will be served after the talks

Sponsored by

 

New Players in Ubiquitination: Relevance to innate immunity and inflammatory diseases

MCT Research Forum – March 25th 2019 at Cheyne Lecture Theatre at 3.00pm – 4.00pm

Prof. Paul Moynagh – “New Players in Ubiquitination: Relevance to innate immunity and inflammatory diseases”
Prof. Moynagh obtained his B.A. (Mod) and PhD from Trinity College Dublin and took up a lectureship in UCD Department of Pharmacology in 1995. During his time in UCD Prof. Moynagh became Associate Professor of Immunology and held the position of founding Head of the UCD School of Biomolecular and Biomedical Science. In 2006 he joined National University of Ireland, Maynooth as Director of its Institute of Immunology and currently holds the positions of Head of Department of Biology and Director of the Human Health Research Institute at Maynooth University. Prof. Moynagh has published extensively in the area of immunology-related research and in 2009 was awarded the NUI Centennial Prize for Academic Publishing in Medical and Health Sciences. He was also awarded the 2014 Irish Area Section Biochemical Society (IASBS) medal. This medal is awarded annually to an Irish-based researcher who has made an outstanding contribution during his/her career in the broad area of Biochemistry. Prof. Moynagh’s research focuses on innate immune signalling and the identification of novel regulators of inflammatory pathways with his most recent findings revealing immunomodulatory roles for the Pellino E3 ubiquitin ligases in inflammasome activation (Humphries et al; Nature Communications (2018), antiviral immunity (Siednienko et al; Nature Immunology (2012)), controlling intestinal homeostasis (Yang et al; Nature Immunology (2013)) and regulating insulin resistance (Yang et al; Immunity (2014)). He has generated >€10M of independent research funding and has directed a number of major research initiatives including the coordination of European Commission-funded research programmes. Prof. Moynagh has also played a leading role in the training of PhD students and directed 2 large structured PhD programmes

Dr. Stephanie Annett –“Unravelling the role of FKBPL in obesity”

Dr. Jennifer Dowling – “The Inflammasome: a novel therapeutic target of Hypoxic Brain Injury in Neonates”

All Welcome

Tea/Coffee and Cookies sponsored by

New Advances in Microscopy

MCT Research Forum – Monday 11th March 2019

Microscopic examination of cells

Prof. Judy Harmey: ‘Using in vivo imaging to evaluate a cancer therapeutic’

Dr. Olga Piskareva: ‘ Seeing is believing’

Dr. Ingmar Schoen: ‘Beyond belief: Quantitative Fluorescence Microscopy’

Start Time: 12.00pm – 1.00pm

Chair: Dr. Cormac McDonnell

Sponsored by:

Translating Bio-Repositories into New Clinical Insights

MCT Research Forum – February, 25th 2019 at 12.00, Cheyne LT

Prof. Paul McNally – “Biorepositories in Childhood Cystic Fibrosis: A Journey of Discovery”
Paul graduated from the UCD School of Medicine in 1998. He completed his paediatric medical training in Ireland, and subsequently completed a 2-year MD in Cystic Fibrosis (CF) lung disease in the Royal College of Surgeons in Ireland. Paul undertook pulmonology fellowship training in the Children’s Hospital of Philadelphia from 2007 to 2009. He was appointed as a consultant in Paediatric Respiratory Medicine at Our Lady’s Children’s Hospital (OLCHC) in 2009. In August 2015, Paul was appointed as Associate Professor of Paediatrics at RCSI. Paul is director of the CF centre in OLCHC and leads the CF research group at NCRC. Paul is clinical lead for Paediatric Respiratory Medicine in the Dublin Paediatric Hospitals. He is a board member of the CF Registry of Ireland and the National Children’s Research Centre. Paul is a member of the working group of the National Clinical Programme for Cystic Fibrosis and is a member of the advisory board for the National Clinical Programme for Paediatrics. Paul has recently been appointed as the director of research and innovation for Children’s Health Ireland (Dublin’s three children’s Hospitals). Paul’s main research interest is early CF lung disease, in particular around the question of why some children have more severe lung disease, and how we can detect these children earlier and modify their treatment.

Dr. Michelle Lavin – “The future of data repositories and e-Health in Irish clinical research”
Dr. Michelle Lavin is a Consultant Haematologist and the Clinical Lead for the Irish Personalised Approach to the Treatment of Haemophilia (iPATH) study, based in the Irish Centre for Vascular Biology, RCSI. She completed her PhD in Trinity College Dublin, focused on the pathophysiology and clinical impact of Low Von Willebrand Factor (VWF) levels. Her research is centred on inherited bleeding disorders; developing insights into phenotypic variability and working to improve clinical outcomes. She serves a Co-Chair on the International Society on Thrombosis and Haemostasis (ISTH) VWF Scientific Subcommittee and a clinical advisor to the World Federation of Haemophilia.

Chair: Soracha Ward
A light lunch will be served after the talks

Sponsored by Biosciences

Genomes and Genome Modification

MCT Research Forum – Monday 11th February 2019 at 3.00pm Houston Lecture Theatre

Chair: Martin Kenny

Speakers:

Prof. Gianpiero Cavalleri

Genome-wide mega-analysis in the epilepsies”

Dr. Cormac McDonnell

“CRISPR strategies for protein engineering”

Dr. Elspeth Ward

“Editing the genome using CRISPR/Cas9”

 Tea/Coffee and Cookies at 2.45pm sponsored by

MCT Research Forum – Friday 25th January at 3.00pm

Professor David Ray

“Circadian control of inflammation; stories from the lung”

David trained in general internal medicine in North West England, and obtained a PhD from the University of Manchester. He was a research fellow at UCLA for two years, working on neuroendocrine-immune interaction, before returning to the UK, and obtaining a GSK fellowship to work on glucocorticoid action, and sensitivity in inflammatory disease. He was promoted to Professor of Medicine at the University of Manchester in 2005, and went on to study nuclear receptor and circadian biology in inflammation, and energy metabolism. This work attracted Wellcome Investigator and MRC programme grant support. David is a passionate advocate of research training, serving on the MRC clinical fellowship panel for seven years, three as deputy chair.

Circadian mechanisms regulate most mammalian physiology, with particular importance in the regulation of innate immunity, through the macrophage in particular, and energy metabolism, regulating liver, adipose and muscle. These circuits are also regulated by a number of nuclear receptors, which show a striking interdependency on the circadian machinery; some having ligand availability regulated by the clock, others varying in expression level through the day. We have employed a range of approaches to address the physiological importance of the circadian: nuclear receptor system, ranging from population genetics, experimental medicine studies, CRISPR engineered mice, and cell biology. These approaches have discovered how the important dimension of time regulates metabolism, and coordinates diverse tissues to deliver optimal organismal performance. Importantly, we are identifying how external stressors can decouple these systems, with deleterious effects.

Dr. Judith Coppinger

“Increased extracellular vesicles mediate inflammatory signalling in Cystic Fibrosis”

Judith obtained her PhD from Department of Clinical Pharmacology, RCSI in 2004 before undertaking postdoctoral training at the Scripps Research Institute, San Diego, on new folding mechanisms in Cystic Fibrosis. In 2011, she joined the University of California, San Diego as a faculty member before receiving an SFI award and returning to Ireland. In 2013 she became a principal investigator at University College Dublin where she set up basic/translational research programs in Cystic Fibrosis and Cancer (lung/breast). Judith’s overall research has focused on using omics-based approaches to decipher protein interaction networks dysregulated in disease and identify new therapeutics to target these pathways. Her research projects include examining the therapeutic restoration of CFTR using kinase inhibitors in Cystic Fibrosis and examining exosomes in regulating inflammatory signalling in Cystic Fibrosis at the National Children’s Research Centre. Other projects include investigating BAG3 as a therapeutic target regulating signalling transduction pathways in breast/lung cancer subtypes. Dr. Coppinger is a senior lecturer at the RCSI and a principal investigator at National Children’s Research Centre since 2017.

George Timmons

“Mitochondria – A link between innate immunity, metabolism, and the clock”

George Timmons is a PhD student of the Curtis Clock Lab, led by Dr. Annie Curtis and is part of the Department of Molecular and Cellular Therapeutics and Tissue Engineering Research Group at RCSI. George began his PhD in October 2016 and is now in the 3rd year of his studies. The Curtis Clock Lab focuses on circadian immunometabolism – a new field which looks into the relationship between the molecular clock, cellular metabolism, and immune responses. Specifically, George’s project is investigating how the core clock gene Bmal1 impacts upon mitochondrial metabolism and how these metabolic changes can impact upon the inflammatory response of macrophages.

When: January 25th 2019 at 3.00pm – 4.30pm

Where: Cheyne Lecture Theatre

Tea Coffee and Cookies sponsored by Biosciences will be at 2.30pm

MCT Research Forum

Monday 14th January 12.00 – 1.30

Drug Discovery and Development

Prof. Celine Marmion

‘Teaching an Old Drug New Tricks – Developing Multi-Targeted Metallodrug Candidates Beyond Cisplatin’

Prof. Dermot Cox

Challenges in developing small molecule drugs

Hannah Rushe

‘Novel therapeutics to prevent uncontrolled bleeding’

Lunch sponsored by Bioscience at 1.30pm

Venue: Cheyne Lecture Theatre

Ancestral origins of increased breast cancer risk and mortality: blame the parents

MCT Research Seminars – 19th December 2018

Leena A. Hilakivi-Clarke, Ph.D. is a professor of Oncology at Georgetown University. She received PhD in 1987 from University of Helsinki, Finland, where she studied the role of maternal exposures during pregnancy in affecting offspring’s later brain development and behaviour. Next, she was a Fogarty postdoctoral fellow (1987-1990) at the National Institute of Alcohol Abuse and Alcoholism in Bethesda, Maryland. In 1991, she joined the Lombardi Comprehensive Cancer Center at Georgetown University, Washington DC. Since then, Dr. Hilakivi-Clarke has been investigating how maternal dietary exposures or exposures to the endocrine-disrupting chemical during pregnancy affect daughter’s breast cancer risk, response to endocrine therapy and risk of recurrence. She discovered that the effects of maternal exposures are not limited to F1 generation but extend to at least F3 generation (great granddaughters). In addition, she has studied the effect of these exposures on mother’s breast cancer risk as well as the impact of childhood exposures on breast cancer risk and recurrence. Exposures include ethinyl estradiol, plant-derived phytochemicals, dietary fats and obesity. Her current goals include being able to identify breast cancer patients who have been ancestrally exposed to factors that may impair their response to endocrine therapy and/or increase their risk of recurrence using their pretreatment tumours. She is also exploring combination therapies, including HDAC/DNMT inhibitors and immune therapies that would prevent recurrence in daughters ancestrally exposed to factors that impair their response to antiestrogens. Her publication record consists of over 160 journal articles. She is a recipient of multiple grant awards through her research career, including being a program director for NCI funded U54 program project entitled “Timing of dietary exposures and breast cancer risk” to investigate nutritional modulation of genetic pathways leading to breast cancer.

Time: 1.00pm – 2.00pm

Venue: Bouchier-Hayes Auditorium, No 26 York St

Lunch will be at 12.30 outside the Auditorium

All Welcome!

PhD student elevator pitch session

Chairs: Thomas Frawley and Orla Fox

Venue: Houston Lecture Theatre

Date: December, 3d 2018

Time: 12.00

Presenters: 

Rebecca Watkin

George Timmons

Aisling Rehill

Hannah Rushe

Remsha Afzal

Conor Duffy

Martin Kenny

Frances Nally

Sean Patmore

James O’Siorain

Shannon Cox

Lauren Fagan

A light lunch will be served after the talks. Sponsored by Biosciences Ltd.

All Welcome!